Dive into the Science of the Kohler Mito Lab
A Masterpiece of Evolution - Background
Mitochondria are the molecular foundation of all oxygen-consuming life on Earth. These fascinating organelles are derived as so-called endosymbionts and contain their own DNA. Find out more about these evolutionary masterpieces and become a Mitochondriac! View
Beyond the Double Membrane - Our Research
Are you curious about how we decipher the molecular principles of life? Here you can learn more about our research interests, our models and methods. But no worries, we keep it short and simple. View
Our Projects
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In this project, we employ genome-wide screens to uncover new components and regulators involved in the quality control of mitochondrially-encoded proteins. Following this, we examine the spatiotemporal organization of these systems and unravel the molecular principles underlying their function.
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Ageing is an intricate biological process that significantly influences human health and, by extension, society. In this project, we conduct ageing experiments to understand how mitochondrial protein quality control evolves during ageing, and conversely, how this system impacts cellular health as ageing progresses.
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Parkinson’s disease, the second most common neurodegenerative disease globally, affects over 8 million people. In this project, we operate under the primary hypothesis that alterations in mitochondrial protein biosynthesis serve as a critical onset point for pathological changes in Parkinson’s disease. We delve into the molecular underpinnings of these processes to further our understanding.
